Deworming in Animals

Deworming in Animals

Deworming:

Deworming is the procedure by which we remove the parasites by the use of certain drugs which are effective against parasites.

Dewormer:

Dewormer is a drug which is used to evacuate the worms from the animal body.

Properties of an Ideal Dewormer

1. Should effectively remove worms from the host

2. Should have wide therapeutic index

3. Should be more toxic to parasites than its host

4. Should be economical to use

5. Administration should be easy.

6. Single dose should be effective.

7. Should be effective in a reasonable bulk.

8. Should not require interruption in normal life not should cause any check in its development.

9. Should not exceed approved limits of drugs residue.

Commonly Used Dewormers – Mechanism of Action and Dose Rate

Niclosamide (Mansonil)

Mode of action: It acts as taenicide by inhibiting the absorption of glucose by tapeworm and stops their oxidative phosphorylation resulting in accumulation of lactic acid.

Dose rate: Cat /Dog 100-157mg /kg PO  Cattle 50mg/kg PO   Sheep/Goat 100mg/kg PO

Bithional

Mode of action: It decrease glycolytic and oxidative metabolism of worm

Dose rate: Goat/Sheep/Cat/Dog 200mg/kg PO

Pyrantel tartrate

It is depolarizing neuromuscular blocking agent thus paralyze the parasite by causing their contracture Dose rate: Horse 12mg/kg PO Cattle 25mg/kg PO

Thiabendazole (Thibenzole)

It inhibits the enzyme fumarate reductase thus interfere with metabolic pathway essential to helminthes. Dose rate Horse 50-100mg/kg PO

Oxfendazole (Oxafex)

Horse 20-25mg/kg PO

Levemisole (Nilverm, Levasole)

It act by blocking the metabolic pathway responsible for formation of ATP

Dose rate: Cattle  15mg/kg PO

Oxyclozanide (Zanil)

It is affective as fasciaolicide and is less toxic

Dose rate: Sheep 15mg/kg PO

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